The symptoms of the common cold are believed to be primarily related to the immune response to the virus. The mechanism of this immune response is virus specific. For example, the rhinovirus is typically acquired by direct contact; it binds to human via ICAM-1 receptors and the CDHR3 receptor through unknown mechanisms to trigger the release of inflammatory mediators. flu” is used to describe an illness with symptoms of diarrhea, nausea, and vomiting, but the “stomach flu” is not the same thing as influenza. Oklahoma State Department of Health Acute Disease Service Public Health Fact Sheet Cold vs. Flu: Know the Difference For more information call or visit us on the web: Rhinovirus and the Common Cold Fact Sheet. There over 62 million annual occurrences of the common cold along with 20 million school days lost annually in the United States according to the National Center for Health Statistics. Rhinoviruses are estimated to be the culprit for about 35% of these cases.